Our research at the Huntsman Cancer Institute focus on digital spatial profiling. We develop hypothesis-driven, multiplexed tissue staining panels for analysis of cell adhesion/invasion/metastasis, DNA damage repair, chromosomal instability and cell plasticity. Dr. Wei Zhang develops the image analysis workflows using Qpath and other open source software solutions and extracts features from cell populations for biomarker development.
Meet our Collaborators
Wei Zhang, Mei Yee Koh, Deepika Sirohi, Jian Ying, Ben J. Brintz, Beatrice S. Knudsen
J Pathol Inform. 2023; 14: 100196
ONECUT2 AND CELL PLASTICITY IN PROSTATE CANCER
Racial disparities in ONECUT2 – KAISO interactions with clinical significance
Collaborator: Michael R. Freeman - Cedars Sinai Medical Center
Sophia Akinbo Masters student in the Master of Science in Laboratory Medicine and Biomedical Science Program
Nature Medicine 2018 - ONECUT2 is a targetable master regulator of lethal prostate cancer that suppresses the
androgen axis
bioRiv 2023 - ONECUT2 Activates Diverse Resistance Drivers of Androgen Receptor-Independent Heterogeneity in Prostate Cancer
CHROMOSOMAL INSTABILITY & DNA DAMAGE REPAIR IN PROSTATE CANCER
Collaborator: Anne Cress – University of Arizona
