Steven Baker Lab
The Baker Lab has two major areas of investigation. The first is understanding lifespan evolution among species. We are developing computational and biochemical tools to uncover the mechanisms leading to the vast differences in lifespan observed in nature.
Our second major area of research involves work on Cerebral Creatine Deficiency Syndromes (CCDSs). We are seeking treatment strategies for these disorders.
Kimberley Evason Lab
The overarching goal of the Evason laboratory is to investigate mechanisms involved in liver tumorigenesis in order to develop improved therapies to treat this deadly cancer. A major subset of HCC is defined by mutations in the CTNNB1 gene encoding β-catenin, an integral component of the Wnt signaling pathway . These β-catenin-activated HCC represent 20-40% of human HCC, and our current research focuses primarily on these tumors.
Keke Fairfax Lab
IL-4 and immuno-modulation are hallmarks of parasitic infections, my laboratory broadly focuses on using the helminth parasite Schistosoma mansoni as a tool to understand both, the consequences of IL-4 induced immuno-modulation, and the complex interplay between B, T, and stromal cells necessary to develop an optimal T and B cell memory response.
Allie Grossmann Lab
Our laboratory focuses on understanding mechanisms of cancer progression and developing clinical interventions. Our goals are to 1) uncover novel mechanisms of tumorigenesis and metastasis, 2) identify biomarkers that prognosticate disease progression or predict treatment response and 3) collaborate with industry to develop new therapies for the prevention and treatment of cancer progression.
Hans Haecker Lab
The major focus of our lab is on innate immunity and inflammation, with projects ranging from molecular mechanisms of signal transduction to translational aspects of drug development. We explore how innate immune cells recognize and respond to pathogens, how genetic mutations in innate immunity contribute to inflammatory and auto-immune diseases, and how obtained information can be used to develop novel therapeutic strategies.
Jarrod Johnson Lab
We study how our cells detect and respond to viral threats. We integrate cell biology, virology, immunology, biochemistry, and functional genomics approaches to tackle questions such as: How are viruses recognized during infection? What cell factors are required for innate immune responses? And how do our cells “tune” immune responses once they are engaged? We hope to learn how viruses like HIV evade detection and uncover new ways to harness our body’s natural defense systems.
Wan-Lin Lo Lab
The Lo Lab deciphers how T cell fate is sealed by an efficient and reliable signal propagation network that begins when a T cell receptor encounters a ligand and discriminates between foreign and self-antigens. We investigate how T cells respond to environmental stimuli to shape their differentiation and stemness, calibrate their sensitivity to activation signals, and establish the extent and specificity of their responses.
Patrice Mimche Lab
The mission of the Mimche laboratory research program is to perform innovative and cutting-edge research aimed at deciphering the biological processes that promote pathological tissue inflammation and fibrosis. Human fibrotic diseases are a major socioeconomic burden on modern societies and account for up to 45% of deaths in the developed world. My group is currently focused on elucidating the role of the axonal guidance cue Eph/Ephrin system in tissue inflammation and fibrogenesis across various organs including the liver, skin, lung, heart, and kidney. To achieve this goal, we utilize cutting edge molecular biology techniques, genetic manipulation of mice, animal modeling of disease, and translational studies in humans. Our ultimate goal is to develop therapy targeting this cell signaling system for the treatment of fibrotic diseases.
Melissa Reeves Lab
The Reeves Lab has established a powerful novel system to model tumor heterogeneity in vivo, in which we can establish and modulate heterogeneous tumors made up of multiple, fluorescently-labeled tumor populations. Using the fluorescent labels, we can track each population within the tumor to study how heterogeneity shapes the spatial organization of immune cells and immune activity within a tumor. We are also investigating the impact of neoantigen heterogeneity—which arises from mutation heterogeneity—on the anti-tumor T cell response, and tumor evolution following immunotherapy.